Esther Hoffenberg began her career in 1980 as a director and producer in Belgium. She co-directed As If It Were Yesterday with Myriam Abramowicz, which was the first film about how Jewish children were saved during World War II by Belgians and Resistance networks. It was distributed theatrically in the United States and France, and with the support of the Royal Belgian Cinematheque, was recently restored.

In 1984, Esther initiated IMAJ (Institut de la mémoire audiovisuelle juive), a non-profit organization dedicated to promoting and preserving films on Jewish themes.

After five years of distributing films with the Parisian team of the National Film Board of Canada, she created her own company, LAPSUS. Lapsus' first film, Charlotte? Life or Theater? was co-produced in 1992 by The Pompidou Center and led to the first exhibition of Charlotte Salomon’s work in France. Over the years, LAPSUS has produced over 60 documentaries that screened at major international film festivals.

In 2005, Esther directed The Two Lives of Eva, a personal documentary about her mother’s moving, tragic life. Since then, she has become increasingly involved in filmmaking with a focus on women including Denise Glaser, Violette Leduc and Bernadette Lafont. In 2009, she directed a short film, My Father, about her father, Sam Hoffenberg, who survived the Warsaw Ghetto.

In 2022, a special program dedicated to her films on women was organized by France’s National Library. Esther is currently working on a film project that will be a sequel to The Two Lives of Eva.